{"id":1829,"date":"2021-07-05T13:07:15","date_gmt":"2021-07-05T13:07:15","guid":{"rendered":"https:\/\/yzcsu.com\/?p=1829"},"modified":"2021-11-12T02:28:37","modified_gmt":"2021-11-11T18:28:37","slug":"mrna","status":"publish","type":"post","link":"https:\/\/yzcsu.com\/mrna\/","title":{"rendered":"\u5a1b\u6a02\u57ce\uff0f\u4e0d\u53ea\u6297\u65b0\u51a0\uff01\u91ab\uff1a\u5c07\u67093\u7a2emRNA\u75ab\u82d7\u554f\u4e16\u9810\u9632\u75be\u75c5"},"content":{"rendered":"\n
\"mRNA\u75ab\u82d7\u9700\u8981\u6975\u4f4e\u6eab\u7684\u51b7\u85cf\u8a2d\u5099\u3002\u8def\u900f\"\/<\/figure>\n\n\n\n

\u5c0dCOVID-19\u75c5\u6bd2\u75ab\u82d7\uff0c\u5f88\u5927\u8ca2\u737b\u7684\u56e0\u7d20\u4e4b\u4e00\uff0c\u5c31\u662f\u4eba\u985e\u958b\u59cb\u63a1\u7528\u4e86\u6700\u65b0\u7684\u300cmRNA\u75ab\u82d7\u300d\u6280\u8853\u4f5c\u70ba\u75ab\u82d7\u751f\u7522\u3002
\u5927\u5bb6\u90fd\u4e00\u5b9a\u4ee5\u70ba\u300cmRNA\u75ab\u82d7\u300d\u6280\u8853\uff0c\u53ea\u4f5c\u70baCOVID-19\u75ab\u82d7\u4f7f\u7528\u800c\u5df2\uff0c\u6211\u5011\u624d\u53ea\u6709\u4e86Moderna\u548cBNT\u75ab\u82d7\uff0c\u4f60\u5011\u90fd\u932f\u4e86\uff01<\/p>\n\n\n\n

\u300cmRNA\u75ab\u82d7\u300d\u6280\u8853\u6a6b\u7a7a\u51fa\u73fe\uff0c\u662f\u4eba\u985e\u75ab\u82d7\u7684\u91cc\u7a0b\u7891\uff0c\u53ef\u4ee5\u60f3\u50cf\u6210\u9019\u662f\u75ab\u82d7\u7684\u6a19\u9776\u85e5\u7269\uff0c\u9019\u4e9b\u90fd\u662f\u4eba\u985e\u672a\u4f86\u300c\u9810\u9632\u75be\u75c5\u5a1b\u6a02\u57ce<\/a>\u300d\u7684\u91cd\u8981\u5de5\u5177\u3002<\/p>\n\n\n\n

\u56e0\u70ba\u7522\u751fmRNA\uff0c\u53ef\u4f5c\u7528\u65bc\u4efb\u4f55\u75be\u75c5\u9810\u9632\u7684\u6a19\u9776\uff0c\u56e0\u6b64\u672a\u4f86\u662f\u9810\u9632\u5404\u7a2e\u75be\u75c5\u7684mRNA\u75ab\u82d7\uff0c\u800c\u4e0d\u6703\u53ea\u662fCOVID-19 \u75c5\u6bd2\u75ab\u82d7\u3002<\/p>\n\n\n\n

\u64da\u79d1\u5b78\u7814\u7a76\u5831\u5c0e\uff0c\u7814\u7a76\u4eba\u54e1\u6b63\u5728\u7814\u7a76\u7684\u300c\u4e09\u7a2emRNA\u75ab\u82d7\u300d\u5c07\u6709\u52a9\u65bc\u9810\u9632\u5404\u7a2e\u75be\u75c5\u3002<\/p>\n\n\n\n

\u764c\u75c7\u75ab\u82d7
\u9810\u9632\u764c\u75c7\u75c5\u6bd2\u50b3\u64ad\u7684\u75ab\u82d7\u5df2\u7d93\u5b58\u5728\u3002\u6bd4\u5982B\u809d\u75ab\u82d7\u53ef\u4ee5\u9810\u9632\u4e00\u4e9b\u809d\u764c\uff0c\u4eba\u985e\u4e73\u7a81\u75c5\u6bd2(HPV)\u75ab\u82d7\u53ef\u4ee5\u9810\u9632\u5b50\u5bae\u9838\u764c\u3002<\/p>\n\n\n\n

\u7136\u800c\uff0c\u7531\u65bcmRNA\u75ab\u82d7\u7684\u9748\u6d3b\u6027\uff0c\u4eba\u5011\u6b63\u5728\u95dc\u6ce8\u958b\u767c\u4e0d\u50c5\u53ef\u4ee5\u9810\u9632\u75c5\u6bd2\u5f15\u8d77\u7684\u764c\u75c7, \u800c\u4e14\u53ef\u4ee5\u9810\u9632\u5404\u7a2e\u764c\u75c7\u7684\u75ab\u82d7\u3002<\/p>\n\n\n\n

\u764c\u75c7\u816b\u7624\u542b\u6709\u6b63\u5e38\u7d30\u80de\u4e2d\u6c92\u6709\u7684\u6297\u539f\u548c\u86cb\u767d\u8cea\u3002<\/p>\n\n\n\n

\u5982\u679c\u53ef\u4ee5\u8a13\u7df4\u514d\u75ab\u7cfb\u7d71\u8b58\u5225\u9019\u4e9b\u816b\u7624\u76f8\u95dc\u6297\u539f\uff0c\u514d\u75ab\u7d30\u80de\u5c31\u6709\u53ef\u80fd\u6467\u6bc0\u764c\u7d30\u80de\u3002<\/p>\n\n\n\n

\u764c\u75c7\u75ab\u82d7\u662f\u9019\u4e9b\u6297\u539f\u7684\u7279\u5b9a\u7d44\u5408\uff0c\u6709\u85e5\u5ee0\u5df2\u8457\u624b\u958b\u767c\u9032\u884c\uff1a<\/p>\n\n\n\n

1.BioNTech\u8207\u8f1d\u745e\u5408\u4f5c\u958b\u767c\u4e86\u4e00\u7a2emRNA\u75ab\u82d7\u91dd\u5c0d\u60e1\u6027\u9ed1\u8272\u7d20\u7624\u6709\u6548\u7684\u764c\u75c7\u75ab\u82d7\u3002<\/p>\n\n\n\n

2.\u5fb7\u570b\u751f\u7269\u88fd\u85e5\u516c\u53f8CureVac\u6b63\u5728\u958b\u767c\u80ba\u764c\u7684\u75ab\u82d7\uff0c\u8a72\u75ab\u82d7\u5df2\u5728\u65e9\u671f\u81e8\u5e8a\u8a66\u9a57 (Phase 1)\u4e2d\u53d6\u5f97\u6210\u529f\u3002<\/p>\n\n\n\n

3.Moderna\u516c\u53f8\uff0c\u8a2d\u8a08\u51fa\u4e00\u7a2e\u5c0d\u6bcf\u500b\u60a3\u8005\u7684\u816b\u7624\u90fd\u6709\u7368\u7279\u4f5c\u7528\u7684\u75ab\u82d7\uff0c\u4ee5\u8a13\u7df4\u500b\u4eba\u7684\u514d\u75ab\u7cfb\u7d71\u4e26\u8a13\u7df4\u8eab\u9ad4\u5c0d\u6297\u764c\u75c7\u3002\u9019\u5a1b\u6a02\u57ce<\/a>\u500b\u7814\u7a76\u6b63\u5728\u7b2c\u4e8c\u968e\u6bb5\u8a66\u9a57(Phase 2)\u4e2d\uff0c\u4ed6\u5011\u751a\u81f3\u671f\u5f85\u5f80\u500b\u4eba\u5316\u7684\u6297\u764cmRNA\u75ab\u82d7\u767c\u5c55\u3002<\/p>\n\n\n\n

\u842c\u7528\u7684\u6d41\u611f\u75ab\u82d7
\u5982\u679c\u6709\u4e00\u7a2e\u75ab\u82d7\u53ef\u4ee5\u4fdd\u8b77\u8eab\u9ad4\uff0c\u514d\u53d7\u6240\u6709\u75c5\u6bd2\u682a\u7684\u4fb5\u5bb3\uff0c\u5c31\u6c92\u6709\u5fc5\u8981\u6bcf\u5e74\u70ba\u65b0\u7684\u75c5\u6bd2\u682a\u63a5\u7a2e\u75ab\u82d7\u3002<\/p>\n\n\n\n

1.Moderna\u516c\u53f8\uff0c\u91dd\u5c0d\u5b63\u7bc0\u6027\u6d41\u611f\u7684mRNA\u75ab\u82d7\u958b\u767c\u8a08\u5283\u3002\u8a72\u8a08\u5283\u91dd\u5c0d\u4e16\u754c\u885b\u751f\u7d44\u7e54 (WHO) \u9810\u6e2c\u5c07\u6d41\u884c\u7684\u56db\u7a2e\u6d41\u611f\u75c5\u6bd2\u682a\uff0c\u627e\u51fa\u9019\u4e9b\u75c5\u6bd2\u682a\u901a\u7528\u7684\u6d41\u611f\u75ab\u82d7\u3002<\/p>\n\n\n\n

\u901a\u904e\u6536\u96c6\u6709\u95dc\u6d41\u611f\u57fa\u56e0\u7d44\u7684\u5927\u91cf\u6578\u64da\uff0c\u7814\u7a76\u4eba\u54e1\u627e\u5230\u4e86\u8a72\u75c5\u6bd2\u6700\u300c\u9ad8\u5ea6\u56fa\u5b9a\u300d\u7684 mRNA \u4ee3\u78bc\u3002<\/p>\n\n\n\n

\u300c\u9ad8\u5ea6\u56fa\u5b9a\u300d\u7684mRNA\u4ee3\u78bc\uff0c\u4e5f\u5c31\u662f\u9019\u7a2e mRNA \u4ee3\u78bc\u6700\u4e0d\u53ef\u80fd\u56e0\u7a81\u8b8a\uff0c\u800c\u5f15\u8d77\u75c5\u6bd2\u86cb\u767d\u7684\u7d50\u69cb\u6216\u529f\u80fd\u7a81\u8b8a\u3002<\/p>\n\n\n\n

\u7814\u7a76\u5c0f\u7d44\u6210\u529f\u88fd\u5099\u4e86\uff0c\u9054\u56db\u7a2e\u4e0d\u540c\u75c5\u6bd2\u86cb\u767d\u7684mRNA\u6df7\u5408\u7269\uff0c\u91dd\u5c0d\u9019\u500b\u842c\u7528\u7684\u6d41\u611f\u75ab\u82d7\u63a5\u7a2e\u767c\u5c55\u4e2d\u3002<\/p>\n\n\n\n

2.\u52d5\u7269\u5be6\u9a57\u5df2\u7d93\u6709\u6548\uff0c\u5c0d\u5c0f\u9f20\u7684\u7814\u7a76\uff0c\u767c\u73fe\u9019\u7a2e\u5be6\u9a57\u6027\u75ab\u82d7\uff0c\u53ef\u4ee5\u91dd\u5c0d\u591a\u7a2e\u6d41\u611f\u75c5\u6bd2\u682a\uff0c\u540c\u6642\u975e\u5e38\u6709\u6548\u3002<\/p>\n\n\n\n

\u7814\u7a76\u4eba\u54e1\uff0c\u4e5f\u6b63\u5728\u81f4\u529b\u65bc\u4eba\u9ad4\u5167\u7684\u300c\u842c\u7528\u6d41\u611f\u75ab\u82d7\u300d\u7684\u958b\u767c\u8a08\u5283\u4e2d\u3002<\/p>\n\n\n\n

\u7627\u75be\u75ab\u82d7
\u7627\u75be\u662f\u7531\u55ae\u7d30\u80de\u5bc4\u751f\u87f2\u7627\u539f\u87f2\u5f15\u8d77\u7684\u4e00\u7a2e\u50b3\u67d3\u75c5\uff0c\u7531\u868a\u87f2\u53ee\u54ac\u5f15\u8d77\u3002<\/p>\n\n\n\n

1.\u845b\u862d\u7d20\u53f2\u514b\u88fd\u85e5\u516c\u53f8\u7684\u7814\u7a76\u4eba\u54e1\u5c08\u5229\u7684\u7627\u75be\u75ab\u82d7\u7de8\u78bc\uff0c\u4e00\u7a2e\u7a31\u70baPlasmodium Migration Inhibitory Factor(PMIF)\u7684\u5bc4\u751f\u87f2\u86cb\u767d\u3002\u901a\u904e\u514d\u75ab\u7cfb\u7d71\u8b58\u522b\u9019\u7a2e\u86cb\u767d\u8cea\u70ba\u76ee\u6a19\uff0c\u5c31\u6709\u53ef\u80fd\u8a13\u7df4\u514d\u75ab\u7cfb\u7d71\u6839\u9664\u5bc4\u751f\u87f2\u3002<\/p>\n\n\n\n

2.\u52d5\u7269\u5be6\u9a57\u5df2\u7d93\u6709\u6548\uff0c\u9019\u7a2e\u7627\u75be\u75ab\u82d7\u5728\u5c0f\u9f20\u5be6\u9a57\u4e2d\uff0c\u4e5f\u53d6\u5f97\u4e86\u4e0d\u932f\u7684\u6210\u679c\uff0c\u4f75\u8a08\u5283\u5728\u82f1\u570b\u9032\u884c\u4eba\u9ad4\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u5a1b\u6a02\u57ce<\/a><\/p>\n\n\n\n

\u9019\u7a2e\u7627\u75bemRNA\u75ab\u82d7\u662f\u4e00\u7a2emRNA\u75ab\u82d7\u53ef\u4ee5\u81ea\u6211\u8907\u88fd\u653e\u5927\uff0c\u7576mRNA\u9032\u5165\u7d30\u80de\u6642\uff0c\u5c31\u6703\u7522\u751f\u4e00\u7d44\u81ea\u6211\u8907\u88fd\u653e\u5927mRNA\u7684\u62f7\u8c9d\u3002\u56e0\u6b64\uff0c\u53ea\u9700\u8981\u751f\u7522\u5c11\u91cf\u7684mRNA\uff0c\u6709\u671b\u6210\u70ba\u7e7c\u73fe\u6709\u6a19\u6e96mRNA\u75ab\u82d7\u4e4b\u5f8c\u7684\u4e0b\u4e00\u4ee3mRNA\u75ab\u82d7\u3002<\/p>\n\n\n\n

mRNA \u75ab\u82d7\u4ecd\u5b58\u6709\u8a31\u591a\u6311\u6230
1.\u51b7\u51cd\u5132\u5b58<\/p>\n\n\n\n

mRNA\u75ab\u82d7\u9700\u8981\u51b7\u51cd\u5132\u5b58\uff0c\u9019\u9650\u5236\u4e86\u5b83\u5011\u5728\u767c\u5c55\u4e2d\u570b\u5bb6\u548c\u504f\u9060\u5730\u5340\u7684\u4f7f\u7528\u3002<\/p>\n\n\n\n

\u76f8\u95dc\u75ab\u82d7\u516c\u53f8\uff0c\u6b63\u5728\u81f4\u529b\u65bc\u958b\u767c\u4e00\u7a2e\u53ef\u4ee5\u51b7\u85cf\u7684mRNA \u75ab\u82d7\u3002\uff08\u9019\u6a23\u4f60\u5011\u8cb7\u75ab\u82d7\uff0c\u4e5f\u9806\u4fbf\u8cb7\u4ed6\u5011\u7684\u51b7\u51cd\u8a2d\u5099\u2026\u2026\u563f\u563f\uff09<\/p>\n\n\n\n

2.\u76e3\u7ba1\u969c\u7919<\/p>\n\n\n\n

\u4efb\u4f55\u65b0\u6280\u8853\u7684\u75ab\u82d7\u554f\u4e16\u7684\u76e3\u6e2c\uff0c\u90fd\u5fc5\u9700\u9032\u884c\u5927\u898f\u6a21\u7684\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n\n\n\n

COVID-19\u75c5\u6bd2\u7684\u5927\u6d41\u884c\uff0c\u5c0e\u81f4mRNA\u75ab\u82d7\u7684\u5feb\u901f\u6279\u51c6\u53ca\u958b\u767c\uff0c\u66f4\u63d0\u4f9b\u4e86\u5927\u6279\u3001\u73fe\u6210\u7684\u4eba\u9ad4\u5be6\u9a57\uff0c\u70ba\u6b64\u65b0\u6280\u8853\u767c\u5c55\uff0c\u5176\u76e3\u7ba1\u969c\u7919\u6bd4\u5f80\u5e74\u5c0f\u5f88\u591a\u3002<\/p>\n\n\n\n

3.\u6602\u8cb4<\/p>\n\n\n\n

\u53e6\u4e00\u500b\u554f\u984c\u662f\u592a\u8cb4\u4e86\u3002\u500b\u4eba\u5316\u7684mRNA\u764c\u75c7\u75ab\u82d7\u5f88\u6602\u8cb4\uff0c\u4e5f\u4e26\u975e\u6240\u6709\u570b\u5bb6\u90fd\u6709\u5927\u898f\u6a21\u751f\u7522mRNA\u75ab\u82d7\u7684\u65b0\u8a2d\u65bd\u3002<\/p>\n\n\n\n

\u8d85\u4e4e\u4f60\u7684\u60f3\u50cf
\u6211\u5011\u4ee5\u70bamRNA\u75ab\u82d7\uff0c\u53ea\u662f\u70ba\u4e86COVID19 \u75c5\u6bd2\u800c\u5df2\u22ef\u22ef<\/p>\n\n\n\n

\u6b8a\u4e0d\u77e5\uff0c\u4eba\u985e\u5f9e\u6cbb\u7642\u75be\u75c5\u5a1b\u6a02\u57ce<\/a>\u5230\u9810\u9632\u75be\u75c5\u7684\u8de8\u6642\u4ee3\u6703\u958b\u59cb\uff0c\u4ee5\u524d\u8a8d\u70ba\u75ab\u82d7\u63a5\u7a2e\uff0c\u53ea\u70ba\u4e86\u7522\u751f\u6297\u9ad4\u62b5\u6297\u75c5\u6bd2\u3001\u75c5\u7b98\u611f\u67d3\u7684\u3002<\/p>\n\n\n\n

\u73fe\u5728mRNA\u75ab\u82d7\u65b0\u6280\u8853\uff0c\u6703\u6539\u8b8a\u4e86\u6211\u5011\u4e0b\u4e00\u4ee3\u5b50\u5b6b\uff0c\u9032\u5165100\u6b72\u7684\u5065\u5eb7\u751f\u547d\u8457\u624b\u3002<\/p>\n\n\n\n

\u4f60\u770b\u4e0d\u5230\u3001\u611f\u53d7\u4e0d\u5230\u90a3\u500b\u76db\u4e16\uff1f\u4e0d\u8981\u64d4\u5fc3\uff0c\u79d1\u5b78\u5bb6\u5df2\u7d93\u5728\u8457\u624b\u6e96\u5099\u4e86\uff01<\/p>\n\n\n\n

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