\u5a1b\u6a02\u57ce<\/a>Fred Hutchinson\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u7684\u7814\u7a76\u5718\u968a\uff0c\u5229\u7528COVID-19\u75c5\u6bd2\u8868\u9762\u7a81\u51fa\u523a\u7a81\u86cb\u767d(S protein)\u4e2d\uff0c\u5176\u4e2d\u4e3b\u8981\u767c\u751f\u75c5\u6bd2\u548c\u4eba\u9ad4\u6230\u722d\u8d77\u521d\u5730\u9ede\uff0c\u53eb\u300c\u53d7\u9ad4\u7d50\u5408\u9ede\uff08RBD\uff09\u300d\u7684\u90e8\u5206\u3002<\/p>\n\n\n\n\u65e9\u5728\u53bb\u5e745\u6708\u5de6\u53f3\uff0c\u77e5\u540d\u79d1\u5b78\u671f\u520a\u300aScience\u300b\u62cd\u4e86COVID-19\u75c5\u6bd2\u7684\u86cb\u767d\u6676\u9ad4\u7d50\u69cb\u3002Daniel Wrapp\u7814\u7a76\u5718\u968a\u9032\u4e00\u6b65\u767c\u73fe\uff0c\u300c\u53d7\u9ad4\u7d50\u5408\u4f4d\u9ede\uff08RBD\uff09\u300d\u662f\u4eba\u9ad4\u7d30\u80de\u8868\u9762\u53d7\u9ad4\uff0c\u53ebACE2(Angiotensin I\u2013converting enzyme 2)\u4e3b\u8981\u7d50\u5408\u529b\u7684\u5730\u65b9\u3002<\/p>\n\n\n\n
RBD\u8a6d\u7570\u591a\u7aef<\/h2>\n\n\n\n
RBD\u662f\u4e00\u500b\u5c07\u4eba\u9ad4\u7d30\u80deACE2\u53d7\u9ad4\u8207\u75c5\u6bd2\u523a\u7a81\u86cb\u767d(S protein)\u7d50\u5408\u7684\u4f4d\u9ede\u3002\u5982\u679c\u4eca\u5929RBD\u5340\u57df\u8d77\u4e0d\u4e86\u4f5c\u7528\uff0c\u75c5\u6bd2\u5c31\u7121\u6cd5\u5f88\u597d\u5730\u6ef2\u900f\u5230\u4eba\u9ad4\u7d30\u80de\u4e2d\u3002<\/p>\n\n\n\n
\u6b64\u6b21\u4f86\u81ea\u7f8e\u570b\u897f\u96c5\u5716\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3Jesse Bloom\u548cAllison Greaney\u7684\u7814\u7a76\u5718\u968a\uff0c\u4ed6\u5011\u5c31\u5047\u8a2d\u5982\u679c\u80fd\u5426\u8b58\u5225RBD\uff0c\u5c31\u53ef\u4ee5\u77e5\u9053\u300c\u5f9e\u611f\u67d3\u5eb7\u5fa9\u5f8c\u7372\u5f97\u7684\u514d\u75ab\u300d\u548c\u300c\u5f9e\u75ab\u82d7\u63a5\u7a2e\u5f8c\u7372\u5f97\u7684\u514d\u75ab\u300d\u5169\u8005\u7684\u5dee\u7570\uff0c\u6211\u5011\u5c31\u77e5\u9053\u5f9e\u611f\u67d3\u5eb7\u5fa9\u5f8c\u6216\u5f9e\u75ab\u82d7\u63a5\u7a2e\u5f8c\uff0c\u8ab0\u7372\u5f97\u514d\u75ab\u8f03\u9ad8\u3002<\/p>\n\n\n\n
\u4f46\u662f\uff0c\u7531\u65bcRBD\u4e2d\u53ef\u4ee5\u767c\u751f\u5f88\u591a\u7a81\u8b8a\uff0c\u5373\u4f7f\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u81ea\u7136\u80fd\u5920\u8b58\u5225\u51fa\u7279\u5b9a\u7684RBD\uff0c\u4e5f\u53ef\u80fd\u7121\u6cd5\u61c9\u5c0d\u5177\u6709\u4e0d\u540c\u7d50\u69cb\u7684RBD\u7684\u7a81\u8b8a\u682a\u75c5\u6bd2\u7684\u51fa\u73fe\u3002<\/p>\n\n\n\n
\u7279\u6b8a\u300c\u6383\u63cf\u6cd5\u300d<\/h2>\n\n\n\n
\u56e0\u6b64\uff0c\u7814\u7a76\u5718\u968a\u5f9e\u63a5\u7a2e\u904e2\u5291Moderna mRNA\u75ab\u82d7\u7684\u4eba\u9ad4\u5167\uff0c\u548c\u66fe\u611f\u67d3\u904e\u4e14\u5eb7\u5fa9\u4e2d\u7684\u4eba\u8eab\u4e0a\u6536\u96c6\u6297\u9ad4\uff0c\u7814\u7a76\u5718\u968a\u518d\u5f9e\u6db5\u84cb\u5927\u7d043800\u7a2e\u767c\u751f\u5728RBD\u4e2d\u7684\u7a81\u8b8a\u8cc7\u6599\u5eab\u4e2d\uff0c\u7531\u7279\u6b8a\u5206\u5b50\u6aa2\u67e5\u6280\u8853\u300c\u6df1\u5ea6\u7a81\u8b8a\uff08Deep Mutational Scanning, DMS\uff09\u300d\u505a\u4e86\u5e73\u884c\u6aa2\u67e5\uff0c\u66b8\u89e3\u9019\u4e9b\u4eba\u7522\u751f\u6297\u9ad4\u5c0dRBD\u7522\u751f\u53cd\u61c9\u7a0b\u5ea6\u3002<\/p>\n\n\n\n
\u767d\u8a71\u6587\uff1aDMS\u70ba\u4e00\u7a2e\u300c\u6383\u63cf\u6cd5\u300d\u7684\u6280\u8853\uff0c\u7814\u7a76\u514d\u75ab\u7cfb\u7d71\u662f\u5426\u53ef\u4ee5\u5c0dRBD\u7684\u7a81\u8b8a\uff0c\u505a\u51fa\u9069\u7576\u7684\u53cd\u61c9\u3002<\/strong><\/p>\n\n\n\n\u7814\u7a76\u767c\u73fe<\/h2>\n\n\n\n
1.\u8207\u611f\u67d3\u5f8c\u5f15\u8d77\u7684\u6297\u9ad4\u76f8\u6bd4\uff0c\u75ab\u82d7\u63a5\u7a2e\u5f15\u8d77\u7684\u6297\u9ad4\uff0c\u4e2d\u548c\u6297\u9ad4\u6d3b\u6027\u66f4\u80fd\u91dd\u5c0dCOVID-19\u7684\u53d7\u9ad4\u7d50\u5408\u7aef\uff08RBD\uff09\u53cd\u61c9\u3002<\/p>\n\n\n\n
2.\u5728RBD\u4e2d\uff0c\u8207\u611f\u67d3\u5f15\u767c\u7684\u6297\u9ad4\u76f8\u6bd4\uff0c\u75ab\u82d7\u5f15\u767c\u7684\u6297\u9ad4\u7684\u7d50\u5408\u66f4\u5ee3\u6cdb\u5730\u5206\u4f48\u5728\u5176\u4e2d\u3002\u9019\u7a2e\u66f4\u5927\u5ee3\u5ea6\u7684\u7d50\u5408\uff0c\u610f\u5473\u8457\u8207\u611f\u67d3\u6062\u5fa9\u671f\u7684\u8840\u6e05\u76f8\u6bd4\uff0c\u55ae\u500bRBD\u7a81\u8b8a\u5c0d\u75ab\u82d7\u8840\u6e05\u4e2d\u548c\u6297\u9ad4\u7684\u6fc3\u5ea6\u5f71\u97ff\u6bd4\u8f03\u5c0f\u3002<\/p>\n\n\n\n
3.\u5c08\u5bb6\u6700\u5f8c\u63d0\u9192\uff0c\u81ea\u7136\u611f\u67d3\u5f15\u8d77\u7684\u514d\u75ab\u548c\u75ab\u82d7\u63a5\u7a2e\u5f15\u8d77\u7684\u514d\u75ab\u4e4b\u9593\u7684\u5dee\u7570\uff0c\u63d0\u9192\u5927\u5bb6\u5373\u4f7f\u611f\u67d3\u4e86COVID-19\u75c5\u6bd2\u6062\u5fa9\u5f8c\uff0c\u4ecd\u7136\u9700\u8981\u901a\u904e\u63a5\u7a2e\u75ab\u82d7\uff0c\u7372\u5f97\u5168\u9762\u7684\u4fdd\u8b77\u3002<\/p>\n\n\n\n
\u70ba\u4f55\u75ab\u82d7\u63a5\u7a2e\u7684\u6297\u9ad4\u548c\u611f\u67d3\u5eb7\u5fa9\u5f8c\u7684\u6297\u9ad4\u4e4b\u9593\uff0c\u5b58\u5728\u5982\u6b64\u5927\u7684\u5dee\u7570\uff1f<\/h2>\n\n\n\n
\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002\u70ba\u4ec0\u9ebc\u5b58\u5728\u5982\u6b64\u5927\u7684\u5dee\u7570\u3002<\/p>\n\n\n\n
\u4f46\u7814\u7a76\u4eba\u54e1\u63a8\u6e2c\uff0c\u75ab\u82d7\u662f\u4eba\u5de5\u7279\u610f\u8a2d\u8a08\uff0c\u4ee5\u7a0d\u5fae\u4e0d\u540c\u5f62\u5f0f\u5448\u73fe\u5404\u7a2e\u75c5\u6bd2\u86cb\u767d\uff0c\u4ee5\u9069\u61c9\u4e0d\u540cRBD\u6297\u539f\u6c7a\u5b9a\u5340 (epitope)\u5f62\u72c0\uff0c\u9019\u53ef\u80fd\u5c0e\u81f4\u514d\u75ab\u53cd\u61c9\u7684\u9748\u6d3b\u6027\uff0c\u90fd\u5b58\u5728\u4e3b\u8981\u767c\u751f\u75c5\u6bd2\u548c\u4eba\u9ad4\u6230\u722d\u8d77\u521d\u4ea4\u6230\u6700\u6fc0\u70c8\u5730\u9ede\u3002<\/p>\n\n\n\n
\u800c\u611f\u67d3\u5eb7\u5fa9\u5f8c\u7684\u6297\u9ad4\uff0c\u53ef\u80fd\u53ea\u91dd\u5c0dRBD\u67d0\u4e00\u6297\u539f\u6c7a\u5b9a\u5340(epitope)\u4f5c\u51fa\u53cd\u61c9\u800c\u5df2\u3002<\/p>\n\n\n\n
\u5982\u679c\u6211\u5df2\u611f\u67d3\u904e\u4e86COVID-19\uff0c\u6211\u9084\u8981\u63a5\u7a2e\u75ab\u82d7\u55ce\uff1f<\/h2>\n\n\n\n
\u662f\u7684\u3002<\/p>\n\n\n\n
\u5373\u4f7f\u4f60\u5df2\u7d93\u611f\u67d3\u4e86COVID-19\uff0c\u4f60\u4ecd\u7136\u61c9\u8a72\u63a5\u7a2e\u75ab\u82d7\u3002<\/p>\n\n\n\n
\u56e0\u70ba\u6211\u5011\u5c1a\u4e0d\u77e5\u9053\u4f60\u611f\u67d3COVID-19\u5f8c\u6703\u53d7\u5230\u591a\u9577\u6642\u9593\u7684\u4fdd\u8b77\u3002\u63a5\u7a2e\u75ab\u82d7\u5c07\u63d0\u9ad8\u4f60\u7684\u514d\u75ab\u529b\uff0c\u5f9e\u800c\u66f4\u597d\u3001\u66f4\u9577\u4e45\u5730\u4fdd\u8b77\u4f60\u514d\u53d7COVID-19\u75c5\u6bd2\u7684\u4fb5\u5bb3\uff0c\u5305\u62ec\u66f4\u5177\u50b3\u67d3\u6027\u7684\u75c5\u6bd2\u8b8a\u7570\u682a\u3002<\/p>\n\n\n\n
\u5728\u611f\u67d3COVID-19\u5f8c\uff0c\u63a5\u7a2e\u75ab\u82d7\u662f\u5b89\u5168\u7684\uff0c\u4f46\u4f60\u61c9\u8a72\u7b49\u5230\u9694\u96e2\u671f\u7d50\u675f\u5f8c\u518d\u53bb\u63a5\u7a2e\u3002\u9019\u662f\u70ba\u4e86\u8b93\u4f60\u5728\u63a5\u7a2e\u75ab\u82d7\u6642\u4e0d\u6703\u5c07\u75c5\u6bd2\u50b3\u67d3\u7d66\u91ab\u8b77\u4eba\u54e1\u548c\u5176\u4ed6\u4eba\u3002<\/p>\n\n\n\n
\u5982\u679c\u4f60\u5df2\u7d93\u5eb7\u5fa9\u6cbb\u7642\uff0c\u4f60\u53ef\u4ee5\u7b49\u5f85\u300c90\u5929\u5f8c\u300d\u518d\u63a5\u7a2eCOVID-19\u75ab\u82d7\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
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